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The fatal crash occurred at approximately 3 p.m. on Woodhaven Road (Route 63) near Thornton Road, Philadelphia police said.
The male rider, who was not identified, was traveling eastbound, and collided with both a vehicle and a box truck, also traveling eastbound, police said.
The motorcyclist was pronounced dead by Medic 20 at 3:19 p.m., they said.
Woodhaven Road was closed in both directions during an investigation.
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